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Infectious Disorders - Drug Targets

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ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

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Research Article

Hepatitis E Genotype 1 Outbreak in Jharkhand, India: A Descriptive Analysis

Author(s): Neelam Mehta, Minakshi Gupta, Minakshi Mishra and Santosh Kumar Singh*

Volume 21, Issue 1, 2021

Published on: 17 January, 2020

Page: [99 - 104] Pages: 6

DOI: 10.2174/1871526520666200117112813

Price: $65

Abstract

Introduction: A waterborne outbreak of hepatitis E virus occurred in the Jamshedpur city of Jharkhand from March 2018 to October 2018. The aim of the present study is to study the hepatitis E virus outbreak clinically, serologically and etiologically.

Methods: Five hundred and eighty-four clinically and biochemically documented cases were screened for the hepatotropic viral markers (HepatitisA, B, C, and E) by the ELISA. Demographic data such as gender, age, clinical diagnosis, location, outcome and time of admission were extracted from the online hospital management system. Water samples from the affected area were tested for HEV RNA detection. Genotyping of HEV virus was carried out by sequencing and phylogenetic analysis.

Results: Hepatitis E genotype 1 was confirmed as the major etiological agent in this outbreak due to the faecal contamination of drinking water supply while establishing illegal water connections. Mixed infection of HEV-HAV (5.31%) or HEV-HBV (0.91%) was also detected in the present series of acute viral hepatitis.

Conclusion: The study highlights the importance of screening for both enterically transmitted hepatotropic viral markers as well as the parenterally transmitted hepatotropic viral markers during the outbreaks of acute viral hepatitis.

Keywords: Hepatitis E, outbreak, genotype 1, total bilirubin, serum alkaline phosphatase, serum alanine aminotransferase.

Graphical Abstract

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