Abstract
Antimicrobial peptides (AMPs) are multi-functional peptides whose fundamental biological role in vivo has been proposed to be the elimination of pathogenic microorganisms, including Gram-positive and -negative bacteria, fungi, and viruses. Genes encoding these peptides are expressed in a variety of cells in the host, including circulating phagocytic cells and mucosal epithelial cells, demonstrating a wide range of utility in the innate immune system. Expression of these genes is tightly regulated; they are induced by pathogens and cytokines as part of the host defense response, and they can be suppressed by bacterial virulence factors and environmental factors which can lead to increased susceptibility to infection. New research has also cast light on alternative functionalities, including immunomodulatory activities, which are related to their unique structural characteristics. These peptides represent not only an important component of innate host defense against microbial colonization and a link between innate and adaptive immunity, but also form a foundation for the development of new therapeutic agents.
Keywords: Defensin, magainin, innate immunity, membrane disruption
Current Pharmaceutical Design
Title: The Roles of Antimicrobial Peptides in Innate Host Defense
Volume: 15 Issue: 21
Author(s): Gill Diamond, Nicholas Beckloff, Aaron Weinberg and Kevin O. Kisich
Affiliation:
Keywords: Defensin, magainin, innate immunity, membrane disruption
Abstract: Antimicrobial peptides (AMPs) are multi-functional peptides whose fundamental biological role in vivo has been proposed to be the elimination of pathogenic microorganisms, including Gram-positive and -negative bacteria, fungi, and viruses. Genes encoding these peptides are expressed in a variety of cells in the host, including circulating phagocytic cells and mucosal epithelial cells, demonstrating a wide range of utility in the innate immune system. Expression of these genes is tightly regulated; they are induced by pathogens and cytokines as part of the host defense response, and they can be suppressed by bacterial virulence factors and environmental factors which can lead to increased susceptibility to infection. New research has also cast light on alternative functionalities, including immunomodulatory activities, which are related to their unique structural characteristics. These peptides represent not only an important component of innate host defense against microbial colonization and a link between innate and adaptive immunity, but also form a foundation for the development of new therapeutic agents.
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Cite this article as:
Diamond Gill, Beckloff Nicholas, Weinberg Aaron and Kisich O. Kevin, The Roles of Antimicrobial Peptides in Innate Host Defense, Current Pharmaceutical Design 2009; 15 (21) . https://dx.doi.org/10.2174/138161209788682325
DOI https://dx.doi.org/10.2174/138161209788682325 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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