Molecular Mechanism of Autophagy: Its Role in the Therapy of Alzheimer’s Disease

Yuan       Zhao; Yidan       Zhang; Jian       Zhang; Xiangjian       Zhang; Guofeng       Yang
doi:10.2174/1570159X18666200114163636
Abstract

Alzheimer’s disease (AD) is a neurodegenerative disorder of progressive dementia that is characterized by the accumulation of beta-amyloid (Aβ)-containing neuritic plaques and intracellular Tau protein tangles. This distinctive pathology indicates that the protein quality control is compromised in AD. Autophagy functions as a “neuronal housekeeper” that eliminates aberrant protein aggregates by wrapping then into autophagosomes and delivering them to lysosomes for degradation. Several studies have suggested that autophagy deficits in autophagy participate in the accumulation and propagation of misfolded proteins (including Aβ and Tau). In this review, we summarize current knowledge of autophagy in the pathogenesis of AD, as well as some pathways targeting the restoration of autophagy. Moreover, we discuss how these aspects can contribute to the development of disease-modifying therapies in AD.
Keywords: Alzheimer`s disease, autophagy, amyloid beta, tau, propagation of amyloid beta and tau, mTOR-dependent pathway, mTOR-independent pathway, autophagy-related interventions.
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DOI https://dx.doi.org/10.2174/1570159X18666200114163636	Print ISSN 1570-159X
Publisher Name Bentham Science Publisher	Online ISSN 1875-6190
Current Neuropharmacology

Molecular Mechanism of Autophagy: Its Role in the Therapy of Alzheimer’s Disease

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