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Review Article

对RNA依赖RNA聚合酶抑制剂作为抗流感病毒制剂的见解

卷 28, 期 6, 2021

发表于: 14 January, 2020

页: [1068 - 1090] 页: 23

弟呕挨: 10.2174/0929867327666200114115632

价格: $65

摘要

背景：流感是一种季节性疾病，每年影响数百万人，并具有重大的经济影响。疫苗是对抗这种病毒病理的最佳策略，但它们并非总是可用或可管理，这促使人们寻找抗病毒药物。RNA依赖RNA聚合酶(RdRp)因其在病毒复制中的关键作用以及在病毒株中的高度保守性而成为一个很有前途的靶点。 讨论：本文综述了自2000年以来文献中讨论的最有趣的RdRp抑制剂。本文描述了已获批准或正在进行临床试验的化合物以及赋予不同支架的抑制剂的选择，以及它们活性的主要特征。 结果：RdRp抑制剂正在成为一种对抗病毒感染的新策略，这类药物的重要性已得到FDA 2018年批准的baloxavir marboxil的证实。尽管RdRp机器的复杂性使新化合物的识别成为一个具有挑战性的研究课题，但很可能在未来几年，由于这种治疗方法的潜在优势，该领域将吸引许多学术和工业科学家的兴趣。

关键词: RNA依赖RNA聚合酶抑制剂，甲型流感病毒，蛋白质-蛋白质相互作用抑制剂，小分子，抗病毒药物，PA-PB1抑制剂

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