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Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Review Article

Cell-based Assays for Assessing Toxicity: A Basic Guide

Author(s): Raveen Parboosing, Gugulethu Mzobe, Louis Chonco and Indres Moodley

Volume 13, Issue 1, 2017

Page: [13 - 21] Pages: 9

DOI: 10.2174/1573406412666160229150803

Price: $65

Abstract

Assessment of toxicity is an important component of the drug discovery process. Cellbased assays are a popular choice for assessing cytotoxicity. However, these assays are complex because of the wide variety of formats and methods that are available, lack of standardization, confusing terminology and the inherent variability of biological systems and measurement. This review is intended as a guide on how to take these factors into account when planning, conducting and/or interpreting cell based toxicity assays.

Keywords: Cytotoxicity, cytotoxicity screening, viability assays, apoptosis, cell-based assays, toxicity.

Graphical Abstract


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