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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

左西孟旦预防糖尿病引起的大鼠记忆力减退：氧化应激的作用

卷 16, 期 14, 2019

页: [1300 - 1308] 页: 9

弟呕挨: 10.2174/1567205017666200102153239

价格: $65

摘要

背景：左西孟旦是一种钙敏化剂和磷酸二酯酶抑制剂，具有有效的抗氧化剂和抗炎活性。 目的：本研究的目的是研究左西孟旦对糖尿病引起的学习和记忆障碍的潜在保护作用。 方法：成年Wister大鼠随机分为四组（每组15只）：对照组，左西孟旦，链脲佐菌素（STZ）诱发的糖尿病和左西孟旦-STZ糖尿病。确认STZ糖尿病模型成功后，将腹膜内左西孟旦（100μg/ kg /周）给予指定组4周。然后，采用径向臂水迷宫被用来评估空间学习和记忆。在海马组织中评估了氧化应激生物标志物和脑源性神经营养因子。 结果：结果表明，糖尿病（DM）损害了短期和长期记忆（P <0.01），而左西孟旦可以保护动物免受记忆损害。此外，左西孟旦预防了DM引起的海马超氧化物歧化酶和谷胱甘肽过氧化物酶水平的降低（P <0.05）。此外，左西孟旦的给药防止了DM引起的海马硫代巴比妥酸反应性物质水平的升高（P <0.05）。此外，左西孟旦使DM大鼠中还原/氧化型谷胱甘肽（GSH / GSSG）的比例恢复至对照组（P <0.05）。 结论：总之，DM诱导的学习和记忆障碍，左西孟旦治疗可能通过防止海马中抗氧化系统的改变来阻止这种障碍。

关键词: 链脲佐菌素，活性氧，左西孟旦，糖尿病，记忆力，高血糖症。

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