摘要
背景:尽管急性冠脉综合征(ACS)的治疗最近取得了进展,但ACS患者发生不良心血管事件的风险仍在增加,而其预后仍难以确定。实验和临床研究表明,细胞来源的微颗粒(MPs)与动脉粥样硬化发生的基本病理生理过程有关,可能与动脉粥样硬化血栓形成的诱导有关。 目的:在这篇文章中,我们旨在综述关于MPs在ACS患者中预测作用的现有证据。 结果:证据表明,内皮细胞MPs与ACS患者未来不良心血管事件相关。血小板来源的MPs的研究有很多,因为他们被发现可以触发凝血级联;然而,它们作为未来心血管事件预测因子的作用仍然存在争议。红细胞来源的MPs的作用更有趣;它们被认为是ACS患者血栓形成的标志,而之前的研究表明它们在健康人群中具有抗凝特性。白细胞来源的MPs也可能具有预测作用,尽管这方面的研究仍然有限。最后同样重要的是,循环MPs可以提供关于ACS患者血管造影病变的信息,这是一个有趣的发现。 结论:MPs作为潜在的循环生物标志物在ACS患者中具有很大的前景。然而,需要进行大规模的临床研究来评估血浆MPs的测量是否具有临床意义,从而指导对循环中高水平MPs的患者采取更积极的治疗策略。
关键词: 微粒,急性冠状动脉综合征,内皮细胞源性微粒,血小板源性微粒,急性心肌哽塞,不稳定型心绞痛,预后,效果。
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