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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Review Article

Cell-Derived Microparticles and Acute Coronary Syndromes: Is there a Predictive Role for Microparticles?

Author(s): Effimia Zacharia*, Konstantinos Zacharias, George-Angelo Papamikroulis , Dimitrios Bertsias, Antigoni Miliou, Zoi Pallantza , Nikolaos Papageorgiou and Dimitris Tousoulis

Volume 27, Issue 27, 2020

Page: [4440 - 4468] Pages: 29

DOI: 10.2174/0929867327666191213104841

Price: $65

Abstract

Background: Despite the recent advances in the treatment of Acute Coronary Syndromes (ACS), patients with ACS are still exposed to an increased risk for adverse cardiovascular events, while their prognosis is difficult to determine. Experimental and clinical studies have shown that cell-derived Microparticles (MPs) are associated with the underlying pathophysiological processes that are responsible for atherogenesis and may be causally implicated in the induction of atherothrombosis.

Objective: In the present article, we aimed to review the available evidence regarding the predictive role of MPs in patients with ACS.

Results: Evidence suggests that endothelial MPs are associated with future adverse cardiovascular events in patients with ACS. Platelet-derived MPs have been excessively studied, since they have been found to trigger the coagulation cascade; however, their role as predictors of future cardiovascular events remains debatable. The role of red blood cell-derived MPs is more intriguing; they have been proposed as markers of ongoing thrombosis in patients with ACS, while previous studies have shown that they have anti-coagulant properties in healthy individuals. Leukocyte-derived MPs may also have a predictive role, although the studies regarding these are still limited. Last but not least, it was an interesting discovery that circulating MPs can provide information regarding the angiographic lesions in patients with ACS.

Conclusion: The concept of MPs as potential circulating biomarkers in patients with ACS holds much promise. However, large-scale clinical studies are required to evaluate whether the measurement of plasma MPs could be of clinical significance and, thus, dictate a more aggressive treatment strategy in patients with high levels of circulating MPs.

Keywords: Microparticles, Acute Coronary Syndromes, Endothelium-derived Microparticles, Platelet-derived Microparticles, Acute Myocardial Infarction, Unstable Angina, prognosis, outcomes.

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