摘要
背景：维生素D功能不足与老年人的大脑变化以及认知能力和活动能力下降有关。 目的：我们的目的是调查老年人中维生素D不足<50nmol / L是否与较薄的扣带状皮层有关，扣带状皮层是与维生素D影响的认知功能相关的大脑区域。 方法：215名白人老年人社区居民（平均SD，72.1} 5.5岁；女性占40％）接受了血液检查和脑部MRI检查。使用来自T1加权MR图像的FreeSurfer测量周围的前扣带回皮层，中扣带回皮层和后扣带回皮层的厚度。年龄，性别，教育程度，BMI，平均动脉压，合并症，使用维生素D补充剂或抗血管药物，MMSE，GDS，IADL，血清钙和维生素B9浓度，肌酐清除率作为协变量。 结果：维生素D不足的参与者（n = 80）的总扣带厚度较其他参与者要薄（24.6} 1.9mm对25.3} 1.4mm，P = 0.001）；在所有3个地区中发现了显着差异。维生素D功能不足与横截面总扣带厚度减小有关（β=-0.49，P = 0.028）。血清25OHD浓度与周围前牙（P = 0.011），中扣带（P = 0.013）和后扣带皮层（P = 0.021）的厚度呈正相关。 结论：在研究的老年人样本中，维生素D功能不足与扣带皮层变薄有关。这些发现为维生素D功能不足的老年人认知和活动能力下降的病理生理学提供了见识。
关键词: 脑，扣带回皮层，磁共振成像，老年人，维生素D，记忆障碍。
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