Mini-Review Article

槲皮素在帕金森氏病中的治疗潜力:对其分子和细胞调控的见解

卷 21, 期 5, 2020

页: [509 - 518] 页: 10

弟呕挨: 10.2174/1389450120666191112155654

价格: $65

摘要

帕金森氏病(PD)是一种慢性进行性神经退行性疾病,其特征是黑质致密部(SNc)中的多巴胺能神经元进行性死亡。 PD是一种多因素疾病,提示几种不同的因素起着协同的病理生理作用,包括氧化应激,自噬,潜在的促炎事件和神经递质异常。总体而言,PD可被视为作用于给定遗传背景的环境因素之间复杂相互作用的产物。该主题的重要性已得到更多关注,以发现预防和治疗PD的新疗法。根据先前的研究,用于治疗PD的药物已显示出明显的局限性。因此,类黄酮在PD治疗中的作用已被广泛研究。槲皮素是一种来自类黄酮的植物类黄酮醇,被认为是PD的补充疗法。槲皮素通过控制不同的分子途径在PD中具有药理作用。尽管到目前为止,尚无旨在评估PD情况下槲皮素使用基础的研究,但目前,很少有证据可用于研究潜在的作用机理。这些治疗程序的各个主要方面仍然未知。在此,对支持槲皮素用于PD临床管理的现有知识进行了综述。

关键词: 槲皮素,帕金森氏病,多巴胺,炎性细胞因子,细胞凋亡,自噬。

图形摘要

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