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Review Article

阐明紫杉醇在非小细胞肺癌中的耐药机制及其克服策略的最新进展

卷 27, 期 39, 2020

页: [6573 - 6595] 页: 23

弟呕挨: 10.2174/0929867326666191016113631

价格: $65

摘要

紫杉醇（PTX）是一类一线药物，用于无法从靶向治疗或免疫治疗中受益的晚期非小细胞肺癌（NSCLC）患者。然而，长期治疗患者总是会产生对PTX的耐药性。尽管在文献中已充分证明了导致PTX抗药性的各种机制，但基于这些机制克服NSCLC中PTX抗药性的策略仍具有挑战性。在本文中，我们综述了阐明NSCLC中PTX耐药性的主要机制的最新进展，包括ABC转运蛋白的过表达，微管蛋白结构的改变以及细胞因子，miRNA，激酶信号通路和上皮-间充质转化的参与。还讨论了可能有助于指导治疗决策并恢复细胞对PTX敏感性的PTX耐药性或PTX反应的潜在标志物。最后，我们总结了克服NSCLC细胞中PTX耐药性的相应策略，这可能为临床试验提供新见解，并在将来使肺癌患者受益。

关键词: 紫杉醇耐药性，NSCLC，P-gp，微管，癌细胞存活和凋亡，EMT，活化的激酶途径。

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