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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

Mercury Exposure, Epigenetic Alterations and Brain Tumorigenesis: A Possible Relationship?

Author(s): Geir Bjørklund*, Lyudmila Pivina, Maryam Dadar, Yuliya Semenova, Salvatore Chirumbolo and Jan Aaseth

Volume 27, Issue 39, 2020

Page: [6596 - 6610] Pages: 15

DOI: 10.2174/0929867326666190930150159

Price: $65

Abstract

The risk assessment of mercury (Hg), in both wildlife and humans, represents an increasing challenge. Increased production of Reactive Oxygen Species (ROS) is a known Hg-induced toxic effect, which can be accentuated by other environmental pollutants and by complex interactions between environmental and genetic factors. Some epidemiological and experimental studies have investigated a possible correlation between brain tumors and heavy metals. Epigenetic modifications in brain tumors include aberrant activation of genes, hypomethylation of specific genes, changes in various histones, and CpG hypermethylation. Also, Hg can decrease the bioavailability of selenium and induce the generation of reactive oxygen that plays important roles in different pathological processes. Modification of of metals can induce excess ROS and cause lipid peroxidation, alteration of proteins, and DNA damage. In this review, we highlight the possible relationship between Hg exposure, epigenetic alterations, and brain tumors.

Keywords: Mercury, cancer, brain, reactive oxygen species, homeostasis, CpG hypermethylation.

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