Experimental Cancer Regression by InsP6 & Inositol

Abstract

Towards the eventual goal of translating the cancer inhibitory effect of inositol & InsP₆ seen in experimental animals in vivo to cancer prevention and therapy in humans, studies of human cancer cells lines were performed in vitro; and human cancer cells xenotransplanted in nude mice were used to test the therapeutic potential. A consistent and reproducible broad-spectrum anticancer action of InsP₆ ± inositol was observed in various models; in human breast cancer model InsP₆ showed synergism with standard chemotherapeutic agents Adriamycin or Tamoxifen. Suppression of cancer growth was seen in xenotransplanted rhabdomyosarcoma model and regression of preexisting cancer was seen in hepatoma model. InsP₆ ± inositol also inhibited various steps in cancer metastasis, inositol potentiated the action. These findings are compelling reasons for application of InsP₆+inositol for human cancer control.

Keywords: Adriamycin, CEA, chemotherapeutic agent, collagen, fibronectin, haptotactic migration, HepG2, hepatoma, hepatocellular carcinoma, laminin, MCF-7, MDA MB 231, metastasis, MMP, nude mice, Tamoxifen, TRAMP, synergism, xenotransplantation.