Abstract
Christopher A. Lipinski formulated a rule based on his observation that most drugs administered orally are relatively small and moderately lipophilic molecules. This rule serves as a guideline to determine whether a molecule with specific pharmacological or biological activity possesses properties that would make it a viable orally active drug in humans. Lipinski's Rule of Five functions as a powerful screening tool in the initial phases of drug discovery, enabling researchers to pick molecules with ideal attributes for subsequent development and testing.
Related Journals
Current Chinese Chemistry
Current Analytical Chemistry
Current Catalysis
Current Bioactive Compounds
Current Computer-Aided Drug Design
Current Medicinal Chemistry
The Natural Products Journal
Combinatorial Chemistry & High Throughput Screening
Current Topics in Chemistry
Anti-Cancer Agents in Medicinal Chemistry
Related Books
A Journey Through Water: A Scientific Exploration of The Most Anomalous Liquid on Earth
Advances in Mathematical Chemistry and Applications
Advances in Mathematical Chemistry and Applications
Advances in Mathematical Chemistry and Applications Volume 1 (Revised Edition)
Advances in Organic Synthesis
Advances in Organic Synthesis
Advances in Organic Synthesis
Advances in Organic Synthesis
Advances in Organic Synthesis
Advances in Organic Synthesis