2-Deoxy-D-Glucose and its Derivatives: Dual Role in Diagnostics and Therapeutics

This chapter delves into the multifaceted applications of 2-Deoxy-d-Glucose (2-DG) and its derivatives as versatile tools in diagnostics and therapeutics. Highlighting their dual role in the medical landscape, this chapter provides a comprehensive overview of the diverse functions and mechanisms by which these compounds contribute to both diagnostic assessments and therapeutic interventions. The first section examines the use of 2-DG and its derivatives in diagnostics, detailing their efficacy in various imaging techniques, diagnostic assays, and investigative procedures. Their unique properties and specific interactions in these contexts were explored to elucidate their significance in the accurate detection and visualization of specific physiological conditions or anomalies. The subsequent segment shifts the focus towards the therapeutic realm, where the book chapter investigates the potential and current applications of 2-DG and its derivatives in treating a spectrum of diseases and conditions. From their roles in cancer therapy to neurological disorders and severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) treatment, the chapter outlines the mechanisms and clinical advancements where these compounds show promise as therapeutic agents. Throughout this discussion, the chapter emphasizes the evolving landscape of 2-DG and its derivatives, touching upon ongoing research, challenges, and future prospects in harnessing their dual attributes for enhanced healthcare outcomes. The exploration of these compounds in both diagnostic and therapeutic realms not only illuminates their versatility but also underlines the potential for innovative and integrated medical approaches.