Abstract
Many synthetic procedures for preparing 2-deoxy-D-glucose (2DG) are available in the literature. The synthesis of 2DG involves the modification of glucose at 2-position. Several methods to synthesize 2DG include glucose nitrosation and reductive amination of 2-deoxy-D-arabinose. These methods are highly efficient and produce high yields of 2DG. This chapter discusses various methods for synthesizing 2DG and their advantages and disadvantages. This chapter describes the different approaches for synthesizing 2DG and how the choice of method affects its purity, yield, and properties.
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