Applications of Modern Mass Spectrometry

Volume: 2

Recent Trends of Modern Mass Spectrometry: Application towards Drug Discovery and Development Process

Author(s): Shweta Sharma * .

Pp: 209-224 (16)

DOI: 10.2174/9789815050059124020008

* (Excluding Mailing and Handling)

Abstract

Mass spectrometry has evolved significantly in recent years and has become a powerful analytical tool in the field of drug discovery and development. It allows for the identification and characterization of small molecules, peptides, and proteins in complex biological samples with high sensitivity and accuracy. This chapter provides an overview of the recent trends in modern mass spectrometry and its application towards the drug discovery and development process. It discusses the advancements in mass spectrometry technology, such as high-resolution mass spectrometry (HRMS), ambient ionization mass spectrometry (AIMS), data-independent acquisition (DIA) mass spectrometry, tandem mass spectrometry (LC-MS/MS), and how they have enabled the analysis of complex biological samples. The chapter also highlights the use of mass spectrometry in various stages of the drug discovery and development process, including target identification, hit identification, lead optimization, and drug metabolism and pharmacokinetic studies. Additionally, it discusses the challenges and future prospects of mass spectrometry in drug discovery and development. Overall, mass spectrometry has revolutionized the drug discovery and development process and will continue to play a crucial role in the future.

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