Pharmacological Potential of Bioactive Phloroglucinol Compounds of the Plant Kingdom

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Abstract

Historically, natural products, which are substances generated by living organisms found in nature, have made an important contribution to pharmacotherapy, especially those from plant sources. Phloroglucinols are significant bioactive polyphenolic compounds that are found in plants, marine and microbial sources. Their chemical structures include an aromatic phenyl ring with three hydroxyl groups and are usually made of two or more rings linked together through methylene bridges. They exist widely in several plant families and are known for their significant biological potentials, such as antibacterial, antifungal, anti-inflammatory, antileishmanial, antiplasmodial, antiproliferative and cytotoxicity activities. This book chapter provides an overview of phloroglucinol compounds in the world, their location in the plant, and their pharmacological applications.

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