Nanotechnology in Drug Discovery

Nanotechnology for Drug Design and Drug Delivery

Author(s): Laksiri Weerasinghe*, Imalka Munaweera* and Senuri Kumarage * .

Pp: 108-147 (40)

DOI: 10.2174/9789815238815124010005

* (Excluding Mailing and Handling)

Abstract

The development of ideal, secure, efficient, non-invasive drug delivery systems is now a top priority in this field of drug delivery. Nanoparticles are being employed more frequently for effective medication delivery, exerting the desired therapeutic effect at the expected site of action with the least amount of activity or volume loss. Size, surface chemistry, biological destiny, toxicity, in vivo dispersion, and targeting capabilities all play a role in these systems. The stability and interactions of nanoparticles with cells are regulated by their surface chemistry, and they can access a greater variety of targets. The development of nano-drug delivery systems has opened up new avenues for the treatment and prevention of disease, as well as for enhancing pharmacological properties, enhancing targeting, overcoming drug resistance, and lowering immunogenicity and toxicity. This chapter will first discuss the desirable characteristics of an effective drug delivery system and will cover recent developments in nano drug delivery systems used in clinical research, including dendrimers, solid lipid nanoparticles, nanogels, nanoemulsions, polymeric micelles, and polymer nanofibers.

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