Diabetes and Breast Cancer: An Analysis of Signaling Pathways

Insulin and Hypoxia in Breast Cancer Cell Invasion and Migration

Author(s): Ratul Chakraborty, Debanjana Das, Ayan Goswami, Rajan Rajabalaya, Sheba R. David, Ashok Kumar Balaraman, S. Hemalatha and Asis Bala * .

Pp: 48-65 (18)

DOI: 10.2174/9789815256024124010007

* (Excluding Mailing and Handling)

Abstract

Uncontrolled cell division resulting in cancer is a significant contributor to mortality rates, with breast cancer being the most common form affecting women. When the disease progresses, the uncontrolled cell division can spread through the bloodstream to other parts of the body, making treatment through chemotherapy and radiation therapy challenging. As such, there is an urgent need for the discovery of new drugs and targets to combat this disease. This chapter delves into the physiological role of insulin and hypoxia in breast cancer cell invasion and metastasis, which can potentially increase the druggability of the pathway. It is a valuable resource for those researching new druggable targets in these pathways.

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