Stem Cells in Clinical Application and Productization

The Historical Overview of Stem Cells

Author(s): Leisheng Zhang*, Hao Yu, Wenjing Du, Shuang Chen, Yuan-guang Zhao, Jun Yao* and Cunrong Chen

Pp: 1-17 (17)

DOI: 10.2174/9789815196627124010004

* (Excluding Mailing and Handling)

Abstract

Stem cells of hierarchical clustering have emerged as alternative and promising sources for tissue engineering and regenerative medicine. Owing to the unique self-renewal and multi-lineage differentiation attributes, stem cell-based cytotherapy has evoked great expectations in handling numerous refractory and recurrent diseases. Of note, quality control (QC), good manufacturing practice (GMP), and guidelines for stem cells and the derivations are prerequisites for evaluating the safety and efficacy of stem cell-based remedies. In this book, we principally focus on the definition, classification, signatures and functions, safety and efficacy of stem cells, together with the core concerns upon stem cell-based clinical applications and investigational new drug (IND) and new drug application (NDA). Collectively, this book will effectively benefit the novel stem cell-based tissue engineering and regenerative medicine.

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