Abstract
Coronavirus disease-2019 (COVID-19) is a pandemic disease due to the
infectious virus “Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-CoV-2)”.
Scientifically validated phytoconstituents sourced from “Mother Nature” are now an
area of interest and targeted approach as a worldwide prophylactic measure against
SARS-CoV-2. This section focuses on providing a clear understanding of the structure
of SARS-CoV-2 as well as verified phytoconstituents from traditional medicine (TM)
for addressing the virus with all feasible targets. Target-specific inflammatory
pathways triggered by SARS post-infection include NLRP3, Metallopeptidase Domain
17, JAK-STAT, p38-MAPK, endocytosis pathways e.g. Clathrin, HMGB1 as well as
associated interleukins and cytokines are primarily highlighted, which directly or
indirectly trigger the immune system and play a significant role. Selected Indian
medicinal herbs and their possible leads are detailed below, with the goal of focusing
on specific routes with a high likelihood of preventing pandemics in the future.
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