Abstract
Cancer prevalence across the globe has increased substantially in the last
two decades despite significant progress in inpatient care. Cancer, a multifactorial
disease, evolved several theories to establish pathophysiological conditions.
Uncontrolled proliferation, dedifferentiation and metastasis mainly describe the cancer
progression, which must be characterized by cellular and molecular changes.
Understanding these processes helps devise the strategy for effectively delivering the
drugs to the target sites. The present review described the essential features of cancer
pathophysiology and challenges to achieving drug concentration in the targeted area.
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