Abstract
Cardiovascular disease (CVD) remains one of the leading causes of
morbidity and mortality worldwide with altered lipid metabolism as an important risk
factor. In the current chapter we discuss processes involved in lipid metabolism, the
past and emerging roles of various lipoprotein cholesterol molecules in this process,
free fatty-acid metabolism and the various mechanisms of lipid oxidation and their
impact on vascular physiology in health and disease. We further describe the role of
reverse cholesterol transport (RCT) in the elimination of lipids as bile acids, and finally
discuss current clinical interventions based on emerging technologies against
dyslipidemia, hypertriglyceridemia, and CVD
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