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The Evolution of Radionanotargeting towards Clinical Precision Oncology: A Festschrift in Honor of Kalevi Kairemo

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[99mTc]Tc – MIBI as Oncologic Radiotracer

Author(s): Raluca Mititelu * .

Pp: 329-340 (12)

DOI: 10.2174/9781681088655122010031

* (Excluding Mailing and Handling)

Abstract

Latest advances in PET imaging, the growing importance of the theragnostic
approach and the inclusion of 18F-FDG in the staging guidelines of many oncological
situations put in shadow the research on SPECT radiopharmaceuticals, including those
considered classic as having oncological tropism. However, there are studies, some of
them very recent, that highlight an important role of MIBI in cancer imaging and
management. The dynamics of uptake and the wash-out process differ depending on
the cellular metabolism and can be used for various indications, one of them being
differentiation of malignant processes or predict chemotherapy resistance. In this paper,
we will review the literature and present most important actual and potential
application of 99m-Tc-MIBI scan in oncologic diseases.

Keywords: Chemoresistance, Malignancies, Metabolic Imaging, Nuclear Medicine, Oncology, Radiotracers, 99m-Tc-MIBI.

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