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Review Article

艾滋病毒天冬氨酰肽酶抑制剂的重新定位，以打击被忽视的人类病原体克氏锥虫

卷 26, 期 36, 2019

页: [6590 - 6613] 页: 24

弟呕挨: 10.2174/0929867326666190610152934

价格: $65

摘要

由鞭毛虫锥虫锥虫引起的南美锥虫病是一种众所周知的被忽视的热带病。这种寄生虫病影响6-7百万人，并可能导致严重的心肌炎和/或消化道并发症。其流行病学的变化促进了与人类免疫缺陷病毒（HIV）的共感染，使诊断和预后更加困难。寄生虫感染在克氏锥虫/ HIV合并感染中重新激活，在慢性期出现异常表现，并加剧了典型的临床症状。在所有临床形式中，用于治疗查加斯病的治疗性武器库基本上仅限于两种药物，苯并硝唑和硝呋替莫。两种药物都具有极高的毒性，治疗效果仍不清楚，这使得临床治疗成为亟待解决的巨大问题。因此，显然有必要采取新的切实可行的方法来对抗这种疾病。从这个意义上讲，重新批准药物的定位是一种有趣且可行的策略。人类免疫缺陷病毒天冬氨酰肽酶抑制剂（HIV-PIs）的发现是治疗后天免疫机能丧失综合症（AIDS）的一个里程碑，同时，重要细菌，真菌和寄生虫共病的发病率和患病率也显着降低。清楚地观察到感染。考虑到所有这些发现，本综述总结了关于HIV-PIs对克氏锥虫所有进化形式以及寄生虫生命周期重要步骤的影响的有希望和有益的数据，突出了它们作为替代药物的可能应用治疗南美锥虫病。

关键词: 恰加斯病，克鲁斯锥虫，HIV-PI，药物重新定位，作用方式，生理改变。

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