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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Systematic Review Article

阿尔茨海默氏症痴呆中的铅（Pb）：人类病例对照研究的系统评价

卷 16, 期 4, 2019

页: [353 - 361] 页: 9

弟呕挨: 10.2174/1567205016666190311101445

价格: $65

摘要

背景：阿尔茨海默氏症痴呆（AD）具有复杂的病理生理学，尚未完全了解。慢性，低水平环境铅（Pb）暴露与认知障碍，高血压和死亡率相关，并且已被提议作为AD的潜在原因。 目的：我们旨在回顾文献，以阐明铅在AD中的潜在作用，并指导未来的研究。 方法：通过一系列系统评价，我们确定了病例对照研究，比较AD与对照对6种铅暴露或积累的测量：血液，骨骼，脑脊液，毛发/指甲，死后病理和尿液。我们尽可能完成了元分析。 结果：通过测量方法确定的AD病例对照研究的数量为：血液15，骨骼0，脑脊液（CSF）5，头发/指甲3，死后3，尿液1。报告全血Pb的7项研究和8项血清Pb研究可能有两项荟萃分析。两者都是消极的。最大的CSF Pb研究显示AD水平较低。类似地，在AD中发现较低的头发Pb水平。 结论：现有的病例对照研究不足以得出Pb在AD中的作用。大多数方法不涉及长期或早期暴露。慢性Pb的优选量度是在骨中，其尚未用于病例对照AD研究中。未来的研究应该测量AD中的骨铅，以及其他生物标志物，如淀粉样蛋白和tau成像，以及脑血管病理学的标志物。

关键词: 铅（Pb），阿尔茨海默氏症，痴呆，毒性，环境，认知。

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