Cancer Gene Therapy with Tissue Inhibitors of Metalloproteinases (TIMPs)

Title: Cancer Gene Therapy with Tissue Inhibitors of Metalloproteinases (TIMPs)

Volume: 2 Issue: 2

Author(s): Karsten Brand

Affiliation:

Keywords: Cancer Gene Therapy, Metalloproteinases, Angiogenesis, Tissue Inhibitors

Abstract: Matrix metalloproteinases (MMPs) are of crucial importance for the invasive behavior of primary tumors and their metastases. MMP activity is regulated by the four naturally occurring tissue inhibitors of metalloproteinases (TIMPs). It has been shown that overexpression of TIMPs in tumors of various origins leads to reduced tumor growth and formation of metastases. More recently, antitumor efficacy by in vivo gene transfer of TIMPs has been reported in several clinically relevant animal models. This review analyses the therapeutic potential of the TIMPs from a cancer gene therapeutic point of view with particular emphasis on cell culture and in vivo data.

Cite this article as:

Brand Karsten, Cancer Gene Therapy with Tissue Inhibitors of Metalloproteinases (TIMPs), Current Gene Therapy 2002; 2 (2) . https://dx.doi.org/10.2174/1566523024605564