Regulatory Mechanisms of Chondrogenesis and Implications for Understanding Articular Cartilage Homeostasis

Title: Regulatory Mechanisms of Chondrogenesis and Implications for Understanding Articular Cartilage Homeostasis

Volume: 4 Issue: 3

Author(s): Chisa Hidaka and Mary B. Goldring

Affiliation:

Keywords: chondrogenesis, osteoarthritis, pathogenesis, homeostasis, in articular cartilage, aging

Abstract: Studies of chondrogenesis and embryonic limb development offer a wealth of knowledge regarding signals that regulate the behavior of chondrocytes. Many such chondrogenic regulators are upregulated in osteoarthritis-affected chondrocytes, suggesting a role in pathogenesis. Yet, some of the same factors also support adult articular cartilage homeostasis, and enhance neo-cartilage tissue formation in experimental models. In this review, we summarize many of the important regulatory mechanisms involved in chondrogenesis and examine how their disruption may contribute to functional changes in articular cartilage during osteoarthritis or aging.

Cite this article as:

Hidaka Chisa and Goldring B. Mary, Regulatory Mechanisms of Chondrogenesis and Implications for Understanding Articular Cartilage Homeostasis, Current Rheumatology Reviews 2008; 4 (3) . https://dx.doi.org/10.2174/157339708785133541

DOI https://dx.doi.org/10.2174/157339708785133541	Print ISSN 1573-3971
Publisher Name Bentham Science Publisher	Online ISSN 1875-6360