The Prognostic and Predictive Value of microRNAs in Patients with H. pylori-positive Gastric Cancer

Title:The Prognostic and Predictive Value of microRNAs in Patients with H. pylori-positive Gastric Cancer

Volume: 24 Issue: 39

Author(s): Seyed Mostafa Parizadeh, Reza Jafarzadeh-Esfehani, Amir Avan*, Maryam Ghandehari, Fatemeh Goldani and Seyed Mohammadreza Parizadeh

Affiliation:

• Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad,Iran

Keywords: Gastric cancer, tissue mirna, Helicobacter pylori, normal flora, miRNA, gastric mucosa.

Abstract: Gastric cancer (GC) has a high mortality rate with a poor 5-year survival. Helicobacter pylori (H. pylori) is present as part of the normal flora of stomach. It is found in the gastric mucosa of more than half of the world population. This bacterium is involved in developing H. pylori-induced GC due to the regulation of different micro ribonucleic acid (miRNA or miR). miRNAs are small noncoding RNAs and are recognized as prognostic biomarkers for GC that may control gene expression. miRNAs may function as tumor suppressors, or oncogenes. In this review, we evaluated studies that investigated the ectopic expression of miRNAs in the prognosis of H. pylori positive and negative GC.

Cite this article as:

Parizadeh Mostafa Seyed , Jafarzadeh-Esfehani Reza , Avan Amir *, Ghandehari Maryam , Goldani Fatemeh and Parizadeh Mohammadreza Seyed , The Prognostic and Predictive Value of microRNAs in Patients with H. pylori-positive Gastric Cancer, Current Pharmaceutical Design 2018; 24 (39) . https://dx.doi.org/10.2174/1381612825666190110144254