The Mechanism of Exosomes Function in Neurological Diseases: A Progressive Review

Title:The Mechanism of Exosomes Function in Neurological Diseases: A Progressive Review

Volume: 24 Issue: 24

Author(s): Mengchen Yuan, Nan Liu, Xiaofeng Wang, Chao Tian, Xiaomeng Ren, Hanlai Zhang, Xinyu Yang, Xinye Li, Haiyan Zhu, Lingqun Zhu, Hongcai Shang, Yanwei Xing*Yonghong Gao*

Affiliation:

• Guang'an men Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100053,China

• Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700,China

Keywords: Exosomes, neurological diseases, biomarkers, angiogenesis, neurogenesis, blood brain barrier.

Abstract: Exosomes are extracellular microparticles (≈30–100 nm in diameter) secreted from nearly all types of cells, containing a whole set of biological information including proteins, ribonucleic acid (RNA) and lipids. Latest studies show that exosomes contribute to cell-cell communication and are considered closely related with the modulation of angiogenesis and neurogenesis in many neurological diseases. In the past decade, numerous researchers were devoted to exosomes study, but the mechanism of exosomes function and delivery is uncertain. In this review, we summarized several potential mechanisms of exosomes function in angiogenesis, neurogenesis and Blood Brain Barrier (BBB) delivery, and differentiate various sources of exosomes in stroke, tumor, Traumatic Brain Injury (TBI) and Alzheimer's Disease (AD) aimed to report the most advanced mechanical theories in related past three years to provide a new sight for this research area.

Cite this article as:

Yuan Mengchen , Liu Nan, Wang Xiaofeng , Tian Chao , Ren Xiaomeng , Zhang Hanlai , Yang Xinyu , Li Xinye , Zhu Haiyan , Zhu Lingqun , Shang Hongcai , Xing Yanwei *, Gao Yonghong *, The Mechanism of Exosomes Function in Neurological Diseases: A Progressive Review, Current Pharmaceutical Design 2018; 24 (24) . https://dx.doi.org/10.2174/1381612824666180903113136