Cystoid Macular Edema Due to Accidental Latanoprost Overdose After Uncomplicated Phacoemulsification

Title:Cystoid Macular Edema Due to Accidental Latanoprost Overdose After Uncomplicated Phacoemulsification

Volume: 13 Issue: 3

Author(s): Olga E. Makri, Iasonas K. Tsekouras, Panagiotis Plotas, Foteini Tsapardoni, Athina Pallikari and Constantine D. Georgakopoulos*

Affiliation:

• Department of Ophthalmology, Medical School, University of Patras, Patras,Greece

Keywords: Cystoid macular edema, uneventful phacoemulsification, latanoprost overdose, rechallenge, prostaglandin analogues, best corrected visual acuity, optical coherence tomography.

Abstract: Objective: We present an interesting case of accidental overdose of latanoprost eye drops.

Case Report: A 71-year-old patient underwent an uncomplicated cataract surgery in his right eye. During the first postsurgical week he mistakenly used latanoprost eye drops six times daily instead of the prescribed tobramycin/dexamethasone eye drops. The patient experienced gradually decreasing visual acuity and was diagnosed with cystoid macular edema seven weeks after surgery. The cystoid macular edema resolved 4 weeks later after treatment with nepafenac 0.3% eye drops and oral acetazolamide. The cystoid macular edema recurred 2 weeks after rechallenge with latanoprost. The rechallenge-induced cystoid macular edema once again resolved after cessation of latanoprost and retreatment with nepafenac eye drops. A Naranjo assessment score of 7 was obtained, indicating a probable relationship between the patient’s symptoms and the suspect drug.

Cite this article as:

Makri E. Olga , Tsekouras K. Iasonas , Plotas Panagiotis , Tsapardoni Foteini , Pallikari Athina and Georgakopoulos D. Constantine *, Cystoid Macular Edema Due to Accidental Latanoprost Overdose After Uncomplicated Phacoemulsification, Current Drug Safety 2018; 13 (3) . https://dx.doi.org/10.2174/1574886313666180619163845