The Role of Cyclooxygenase Inhibitors in Cancer Prevention

Title: The Role of Cyclooxygenase Inhibitors in Cancer Prevention

Volume: 8 Issue: 12

Author(s): William F. Anderson, Asad Umar, Jaye L. Viner and Ernest T. Hawk

Affiliation:

Keywords: mf-tricyclio, colorectal carcinogenesis, apc, nin

Abstract: Carcinogenesis results from the long-term accumulation of genetic and epigenetic aberrations at the molecular level, which are under constant selection pressure for growth advantage. Recognizing that cancer is the result of this long-term, multi-step process provides opportunities for molecularly targeted cancer prevention. Ideally, chemopreventive agents should be low in toxicity, morbidity, and cost. Several individual agents and agent combinations are currently under evaluation in the U.S. National Cancer Institutes (NCI) chemoprevention agent development program. Nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclooxygenase (COX) -1 and -2 are among the most promising classes of agents for targeted molecular prevention.

Cite this article as:

Anderson F. William, Umar Asad, Viner L. Jaye and Hawk T. Ernest, The Role of Cyclooxygenase Inhibitors in Cancer Prevention, Current Pharmaceutical Design 2002; 8 (12) . https://dx.doi.org/10.2174/1381612023394935