Flavonoids Acting on DNA Topoisomerases: Recent Advances and Future Perspectives in Cancer Therapy

Title:Flavonoids Acting on DNA Topoisomerases: Recent Advances and Future Perspectives in Cancer Therapy

Volume: 19 Issue: 31

Author(s): P. Russo, A. Del Bufalo and A. Cesario

Affiliation:

Keywords: Cell death, clinical trials, DNA topoisomerases, DNA topoisomerases poisoning, drug discovery and development, flavonoids, phenoxodiol, systems Biology, therapeutic agents, Luteolin

Abstract: Flavonoids, secondary metabolites ubiquitously produced in the plant kingdom, are low molecular weight polyphenolic molecules. They are characterized by variable chemical structures and show a vast array of biological activities (i.e... antiviral, antiinflammatory, antitumor, antimicrobial, estrogenic, antiestrogenic, antioxidant, mutagenic and antimutagenic) targeting different pathways. Some of these compounds such as Genistein, Daidzein or its synthetic derivative Phenoxodiol as well as Luteolin and Quercetin are able to inhibit DNA topoisomerases. This review discusses that Flavonoids targeting DNA topoisomerases may lead to novel drug development with anticancer potential.

Cite this article as:

Russo P., Del Bufalo A. and Cesario A., Flavonoids Acting on DNA Topoisomerases: Recent Advances and Future Perspectives in Cancer Therapy, Current Medicinal Chemistry 2012; 19 (31) . https://dx.doi.org/10.2174/092986712803833272