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Review Article

经典DNA / RNA结合物与核碱基的结合物：化学，生化和生物医学应用

卷 26, 期 30, 2019

页: [5609 - 5624] 页: 16

弟呕挨: 10.2174/0929867325666180508090640

价格: $65

摘要

在生物医学研究中，最深入研究的小分子类别（分子量<650）是与DNA / RNA非共价结合的小分子，而另一个深入研究的类别是核碱基衍生物。在许多书籍和评论中都对这两个课程进行了详尽的阐述。然而，由共价连接至核碱基的DNA / RNA结合物组成的共轭物研究较少，并且在过去的二十年中尚未进行审查。因此，本综述总结了有关经典DNA / RNA结合物-核碱基结合物的设计报告，以及有关其与各种DNA或RNA靶标甚至某些蛋白质靶标相互作用的数据。根据这些数据，提出了小分子与靶标之间选择性甚至特异性识别的最重要的结构方面，并在可能的情况下讨论了相关的生化和生物医学方面。总的结论是，在过去的二十年中，这种相当新的分子类别显示了一套惊人的识别工具，可用于众多的DNA或RNA靶标，而且很少有吸引人的体外和体内选择性。几项主要研究表明，无论是向新颖的，高选择性的标记物还是具有生物活性的，可能具有药物作用的分子，都有望取得进展。

关键词: DNA，RNA识别，芳基-核碱基缀合物，荧光，圆二色性，生物成像，细胞毒性。

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