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Review Article

用于检测酶活性的荧光化学传感器的最新进展

卷 26, 期 21, 2019

页: [3923 - 3957] 页: 35

弟呕挨: 10.2174/0929867325666180214105552

价格: $65

摘要

酶是一类大分子，它们仅需温和的反应条件即可作为高效和特定的生物催化剂发挥作用。酶对于维持生命活动至关重要，包括促进新陈代谢和体内平衡，以及参与多种生理功能。因此，酶的水平和活性与生物体的健康密切相关，其中酶的功能障碍通常导致宿主中相应的疾病。因此，某些疾病的诊断基于某些酶的水平和活性。因此，快速，实时，准确地原位检测酶对疾病的诊断，监测，临床治疗和病理研究很重要。荧光探针在检测酶方面具有独特的优势，包括易于在高灵敏度和选择性的实时快速原位非侵入性和高空间分辨率视觉成像中使用。然而，由于酶反应的过程和类型，荧光探针最常用于检测氧化还原酶，转移酶和水解酶。本文总结了荧光探针在过去五年中检测这三种类型的酶的应用。此外，我们介绍了通过相应的探针检测这些酶的潜在机制。

关键词: 化学传感器，荧光，酶活性，氧化还原酶，转移酶，水解酶。

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