Synthesis and Biological Screening of Lupeol-benzylidine Derivatives

Title:Synthesis and Biological Screening of Lupeol-benzylidine Derivatives

Volume: 8 Issue: 3

Author(s): Devendra S. Rao, Uma Devi Parimi*, Nageswara B. Rao and Karteek A. Rao

Affiliation:

• Department of Chemistry, GIS, GITAM University, Rushikonda, Visakhapatnam, Andhra Pradesh,India

Keywords: Walsura trifoliata, Lupeol, benzylidine derivatives, pentacyclic triterpenoid, anti proliferative activities, claisens condensation.

Abstract: Background: Lupeol, a pentacyclic triterpenoid is found in the stem-bark of Walsura trifoliate. Derivatives of lupeol are associated with a broad range of biological activities.

Objective: To synthesis a series of Lupeol-benzylidine derivatives and evaluate their antimicrobial and antiproliferative acitivities.

Method: Lupeol was isolated from the bark of Walsura trifoliate. The ring A at C2 position of Lupeol was modified by claisens Schmidt condentation to produce Lupeol-benzylidine derivatives. Antimicrobial assay was performed by broth dilution technique.

Results: All the structures were confirmed by 1HNMR, 13CNMR and IR spectroscopic techniques. Compounds 3c and 3h exhibited the highest activity.

Conclusion: In conclusion, a series of different benzylidine derivatives from natural product Lupeol have been synthesized. All the tested compounds are found to be as antimicrobial and antiproliferative agents.

Cite this article as:

Rao S. Devendra , Parimi Devi Uma *, Rao B. Nageswara and Rao A. Karteek , Synthesis and Biological Screening of Lupeol-benzylidine Derivatives, The Natural Products Journal 2018; 8 (3) . https://dx.doi.org/10.2174/2210315508666180117154929