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Review Article

从类黄酮中寻找新的抗真菌药物：白色念珠菌的遗传多样性对体外反应的影响

卷 26, 期 27, 2019

页: [5108 - 5123] 页: 16

弟呕挨: 10.2174/0929867325666171226102700

价格: $65

摘要

背景：在抗菌素耐药性以惊人的速度增长的时代，寻找对传统疗法具有抵抗力的病原微生物有效的新型抗菌剂非常重要。在过去几年天然药物发现研究中的显着突破中，有黄酮类化合物的鉴定和测试，黄酮类化合物是一组植物源性物质，能够促进对人类的多种有益作用。这些化合物显示出不同的生物学活性，例如抑制神经炎症和肿瘤生长以及对许多微生物病原体的抗微生物活性。 方法：我们集中研究了所研究菌株的遗传特性，从而对用于报告类黄酮对白色念珠菌具有抑制作用的研究中使用的方案和标准菌株进行了综述。此外，使用白色念珠菌MLST数据库，我们进行了系统发育分析，显示了该物种中发生的遗传变异。 结果：今天，我们有足够的信息来估计微生物物种内的遗传多样性，而最近的数据表明，大多数真菌病原体显示出复杂的种群结构，其中没有一个分离株可被指定为整个分类单元的代表。对于高度散布的真菌病原体白色念珠菌尤其如此，其中一个或几个“标准品系”可以代表整个物种的假设过于不切实际，应加以搁置。 结论：本文的目的是阐明白色念珠菌的遗传变异程度，以及该现象如何在很大程度上影响类黄酮对该物种的活性。

关键词: 类黄酮，天然化合物，植物提取物，抗菌活性，白色念珠菌，多基因座序列分型，抗真菌剂，基因型。

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