Nanoprecipitation for Poorly Water-Soluble Drugs

Title:Nanoprecipitation for Poorly Water-Soluble Drugs

Volume: 18 Issue: 11

Author(s): Tuong N.G. Nguyen, Van-Thanh Tran, Wei Duan, Phuong H.L. Tran and Thao T.D. Tran*

Affiliation:

• Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City,Vietnam

Keywords: Nanoprecipitation, poorly water-soluble drug, solvent removal technique, surfactant, anti-solvent, nanoparticulate.

Abstract: Background: More than 60% of the active pharmaceutical ingredients, which are classified as Biopharmaceutics Classification System class II. The limited solubility of these drug may lead to low therapeutic effects.

Methods: Nanoprecipitation presents some advantages because it is a straightforward method with low-cost equipment that is easy to scale up.

Results: However, there are two technical issues of concern related to this method. First, the two solvents used for this approach must be miscible; concomitantly, the drug has to be soluble enough in a solvent but not in the antisolvent. Second, the particle growth needs to be adjusted by surfactant addition.

Conclusion: In this review, nanoprecipitation methods and solvent removal techniques for poorly water soluble drugs will be discussed.

Cite this article as:

Nguyen N.G. Tuong , Tran Van-Thanh , Duan Wei , Tran H.L. Phuong and Tran T.D. Thao *, Nanoprecipitation for Poorly Water-Soluble Drugs, Current Drug Metabolism 2017; 18 (11) . https://dx.doi.org/10.2174/1389200218666171004112122