Synthesis of New Bis-Spiropyrazoles as Antitumor Agents under Ultrasound Irradiation

Title:Synthesis of New Bis-Spiropyrazoles as Antitumor Agents under Ultrasound Irradiation

Volume: 18 Issue: 7

Author(s): Naglaa A. Abdel Hafez, Huwaida M.E. Hassaneen, Thoraya A. Farghaly*, Sayed M. Riyadh and Heba S.A. Elzahabi

Affiliation:

• Department of Chemistry, Faculty of Science, Cairo University, Giza 12613,Egypt

Keywords: Antitumor activity, Bis-spiropyrazoles, 3, 5-diarylidene-piperidones, hydrazonoyl halides, spiropiperidinecarbinols, ultrasound irradiation.

Abstract: Objective and Background: Hydrazonoyl halides were used as precursors for the synthesis of a new series of bis-spiropyrazoles via reaction with 3,5-diarylidene-piperidone derivatives under ultrasound irradiation. The products were secluded in good yield after short reaction periods.

Conclusion: The anticancer activity of bis-spiropyrazoles against HepG2 (hepatic cancer), A549 (lung cancer) and CaCo2 (colon cancer) cell lines was screened. Three tested compounds 4b, 4c and 4f showed promising activity.

Cite this article as:

Abdel Hafez A. Naglaa, Hassaneen M.E. Huwaida , Farghaly A. Thoraya *, Riyadh M. Sayed and Elzahabi S.A. Heba , Synthesis of New Bis-Spiropyrazoles as Antitumor Agents under Ultrasound Irradiation, Mini-Reviews in Medicinal Chemistry 2018; 18 (7) . https://dx.doi.org/10.2174/1389557517666170912170027