Fishing Anti-Inflammatories from Known Drugs: In Silico Repurposing, Design, Synthesis and Biological Evaluation of Bisacodyl Analogues

Title:Fishing Anti-Inflammatories from Known Drugs: In Silico Repurposing, Design, Synthesis and Biological Evaluation of Bisacodyl Analogues

Volume: 17 Issue: 25

Author(s): Maité Sylla-Iyarreta Veitía*, Dany Siverio Mota, Vanessa Lerari, Marta Marín, Rosa M. Giner, Liliana Vicet Muro, Yankier Rivero Guerra, Françoise Dumas, Clotilde Ferroud, Peter A. M. de Witte, Alexander D. Crawford, Vicente J. Arán and Yovani Marrero Ponce

Affiliation:

• Equipe de chimie moléculaire, Laboratoire Chimie Moléculaire, génie des procédés chimiques et énergétiques (CMGPCE), EA 7341- Conservatoire National des Arts et Métiers, 2 rue Conté, 75003, Paris,France

Keywords: TOMOCOMD-CARDD Software, Atom-based bilinear indices, Anti-inflammatory database, Bisacodyl, Repurposing, Diarylmethylpyridines, Anti-inflammatory assay.

Abstract: Herein is described in silico repositioning, design, synthesis, biological evaluation and structure-activity relationship (SAR) of an original class of anti-inflammatory agents based on a polyaromatic pharmacophore structurally related to bisacodyl (BSL) drug used in therapeutic as laxative. We describe the potential of TOMOCOMD-CARDD methods to find out new anti-inflammatory drug-like agents from a diverse series of compounds using the total and local atom based bilinear indices as molecular descriptors. The models obtained were validated by biological studies, identifying BSL as the first anti-inflammatory lead-like using in silico repurposing from commercially available drugs. Several biological in vitro and in vivo assays were performed in order to understand its mechanism of action. A set of analogues of BSL was prepared using low-cost synthetic procedures and further biologically investigated in zebrafish models. Compound 5c and 7e exhibited the best antiinflammatory activities and represent new promising anti-inflammatory agents for further preclinical development.

Cite this article as:

Veitía Sylla-Iyarreta Maité *, Mota Siverio Dany , Lerari Vanessa , Marín Marta , Giner M. Rosa , Muro Vicet Liliana , Guerra Rivero Yankier , Dumas Françoise , Ferroud Clotilde , de Witte A. M. Peter , Crawford D. Alexander , Arán J. Vicente and Ponce Marrero Yovani , Fishing Anti-Inflammatories from Known Drugs: In Silico Repurposing, Design, Synthesis and Biological Evaluation of Bisacodyl Analogues, Current Topics in Medicinal Chemistry 2017; 17 (25) . https://dx.doi.org/10.2174/1568026617666170817161953