Natural Steroids and Androgen Antagonists used as Neuroprotection in Common Neurological Disorders

Title:Natural Steroids and Androgen Antagonists used as Neuroprotection in Common Neurological Disorders

Volume: 16 Issue: 7

Author(s): David Calderon Guzman, Hugo Juarez Olguin*, Ernestina Hernandez Garcia, Monica Punzo Soto, Mayra Santillan Garcia and Gerardo Barragan Mejia

Affiliation:

• Laboratory of Pharmacology, National Institute of Pediatrics, Av. Iman No.1, 3rd piso, Colonia Cuicuilco. CP. 04530, Mexico City,Mexico

Keywords: Androgens, antagonist, CNS, neurological disorders, neuroprotectors, steroids.

Abstract: Background & Objective: Multiple classes of natural products, such as antiandrogens or steroids have been used as antioxidants and anti-inflammatory treatments in neurodegenerative diseases. This paper aims to review current knowledge on these substances and their possible relationship with free radicals as an alternative therapy and prevention of common neurological disorders. An exhaustive review of the neurochemical mechanisms of these substances in the central nervous system of humans and animal models is yet to be undertaken in the literature, particularly regarding their importance and increasing use.

Conclusion: Androgen receptor antagonists act in a different way that may underlie the benefits of natural products, with the expectation that in adults, neurological disorders would respond to natural antiandrogens. We hope that this work would provide valuable insight into the protective and therapeutic roles for natural antiandrogens and steroids in common neurological disorders.

Cite this article as:

Guzman Calderon David , Olguin Juarez Hugo *, Garcia Hernandez Ernestina , Soto Punzo Monica , Garcia Santillan Mayra and Mejia Barragan Gerardo , Natural Steroids and Androgen Antagonists used as Neuroprotection in Common Neurological Disorders, CNS & Neurological Disorders - Drug Targets 2017; 16 (7) . https://dx.doi.org/10.2174/1871527316666170714121654