巨噬细胞迁移抑制因子 - 炎症性疾病的有利标志物？

Title:Macrophage Migration Inhibitory Factor - A Favorable Marker in Inflammatory Diseases?

Volume: 25 Issue: 5

关键词: MIF，生物标志物，感染性疾病，自身免疫性疾病，细胞因子，CD74，CXCR。

摘要: Background: Macrophage migration inhibitory factor (MIF) was firstly described in the 1960s as a pleiotropic cytokine affecting a variety of immune cells. Different physiological functions mainly involving inflammatory reactions such as chemokine-like function and regulating systemic stress responses have been reported.

Objective: In several clinical studies the use of MIF as a biomarker has been investigated promising support for diseases with an inflammatory aspect such as sepsis, systemic infections and autoimmune diseases. This article in detail reviews clinical data and evaluates the function as biomarker focusing on inflammatory and autoimmune diseases.

Conclusion: Recent studies suggest MIF to be a marker for different inflammatory diseases and might serve as therapeutic target in the future.

Cite this article as:

Macrophage Migration Inhibitory Factor - A Favorable Marker in Inflammatory Diseases?, Current Medicinal Chemistry 2018; 25 (5) . https://dx.doi.org/10.2174/0929867324666170714114200