LncRNA HOTAIR Polymorphisms Association with Cancer Susceptibility in Different Tumor Types

Title:LncRNA HOTAIR Polymorphisms Association with Cancer Susceptibility in Different Tumor Types

Volume: 19 Issue: 10

Author(s): Gerardo Botti, Francesca Collina, Giosuè Scognamiglio, Gabriella Aquino, Margherita Cerrone, Giuseppina Liguori, Vincenzo Gigantino, Maria Gabriella Malzone and Monica Cantile*

Affiliation:

• Pathology Unit, Istituto Nazionale Tumori Fondazione ,Italy

Keywords: LncRNA, HOTAIR, solid tumors, cancer risk, SNPs, gene expression.

Abstract: Single nucleotide polymorphisms (SNPs) in non-coding RNAs (ncRNA) molecules affect gene and protein expression and generate genetic variability influencing the risk of tumor diseases. HOTAIR locates at the heart of the cell memory gene program and represents a prototype of long non coding RNA (LncRNA) due to its capacity to regulate in-trans a distant chromosome landscape.

Aberrant expression of HOTAIR is frequently associated with pathogenesis and mostly with metastatic progression of several human cancers. Different polymorphisms, particularly present in intronic sequences, as well as in promoter regions of HOTAIR, are often associated with its aberrant expression, patient prognosis, and cancer susceptibility in different tumor phenotypes.

In this minireview, we have summarized the main SNPs in HOTAIR sequence and their relation with cancer risk in several types of solid tumors.

Cite this article as:

Botti Gerardo, Collina Francesca , Scognamiglio Giosuè , Aquino Gabriella, Cerrone Margherita, Liguori Giuseppina, Gigantino Vincenzo , Malzone Gabriella Maria and Cantile Monica *, LncRNA HOTAIR Polymorphisms Association with Cancer Susceptibility in Different Tumor Types, Current Drug Targets 2018; 19 (10) . https://dx.doi.org/10.2174/1389450118666170622091940