药物诱导的治疗性低温在中枢神经系统疾病中的神经保护作用

Title:Neuroprotective Effects of Drug-Induced Therapeutic Hypothermia in Central Nervous System Diseases

Volume: 18 Issue: 12

关键词: 药物诱导的治疗低温，神经保护，脑血管疾病，脑出血，脑缺血。

摘要: Objective: This review article focuses on the neuroprotective effect of drug-induced hypothermia in cerebrovascular diseases and discusses its related side effects.

Method: A systematic literature search was performed using Pubmed and Embase electronic databases for a retrospective analysis.

Results: Experimental studies have shown that drug-induced hypothermia alleviates brain damage and plays a neuroprotective role, thereby reducing mortality and ameliorating neurological deficits. Therefore, drug-induced hypothermia has an important research value and is worth further consideration in the clinical setting. However, drug-induced hypothermia is also associated with side effects, such as ventricular tachycardia, ventricular fibrillation, suppressed immune function, infection, electrolyte imbalance, glucose metabolism disorders, and skeletal muscle tremor. Existing drugs with cooling effects belong to the following categories: (1) dopamine receptor agonists; (2) cannabis; (3) opioid receptors; (4) vanilloid receptors; (5) vasopressins (potent neurotensin receptor agonists); (6) thyroid drugs; (7) adenosine drugs; and (8) purine drugs.

Cite this article as:

Neuroprotective Effects of Drug-Induced Therapeutic Hypothermia in Central Nervous System Diseases, Current Drug Targets 2017; 18 (12) . https://dx.doi.org/10.2174/1389450118666170607104251

DOI https://dx.doi.org/10.2174/1389450118666170607104251	Print ISSN 1389-4501
Publisher Name Bentham Science Publisher	Online ISSN 1873-5592