纳米医学中的Silico模型研究进展

Title:In Silico Models for Nanomedicine: Recent Developments

Volume: 25 Issue: 34

关键词: 纳米粒子，纳米粒子的传递，吸收，药物释放，治疗效果，数学和计算模型。

摘要: Nanomedicine is a recent promising setting for the advancement of current medical therapies, in particular for cancer. Nanoparticle-mediated therapies are aimed to tackle extremely complex phenomena, involving different biochemical, mechanical and biophysical factors. Computational models can contribute to medical research by helping the understanding of biological mechanisms and by providing quantitative analyses. In this work, we report on computational models that address four main issues related to the use of nanoparticles in anti-cancer therapies, namely the delivery of nanoparticles, their uptake by cells, the release of drugs from nano-platforms and nanoparticle-based therapeutics. In silico approaches constitute a valuable tool to aid clinical studies, to guide the rational design of new nanoparticle formulations and to identify the optimal strategies for existing treatments.

Cite this article as:

In Silico Models for Nanomedicine: Recent Developments, Current Medicinal Chemistry 2018; 25 (34) . https://dx.doi.org/10.2174/0929867324666170417120725