Circulating Exosomes as Potential Biomarkers in Cardiovascular Disease

Title:Circulating Exosomes as Potential Biomarkers in Cardiovascular Disease

Volume: 24 Issue: 37

Author(s): Seyed Mostafa Parizadeh, Reza Jafarzadeh-Esfehani, Maryam Ghandehari, Seyed Mohammad Reza Parizadeh, Seyed Mahdi Hassanian, Majid Rezayi, Majid Ghayour-Mobarhan, Gordon A. Ferns and Amir Avan*

Affiliation:

• Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad,Iran

Keywords: Cardiovascular disease, morbidity, mortality, extracellular vesicle, exosome, biomarker.

Abstract: Cardiovascular disease (CVD) is the first leading cause of morbidity and mortality in developing and developed countries. Circulating exosomes have recently been identified as extracellular transporters, detectable in biological fluids. Exosomes have established a new era in diagnosing diseases, especially CVD. Determination of exosome profiles, e.g., miRNAs, for different health states such as myocardial injury still requires further studies. In this review, we will discuss the role of exosomes as a potential biomarker in CVD, with particular emphasis on recent advances in the methods to study exosomes, isolation, detection, and characterization.

Cite this article as:

Parizadeh Mostafa Seyed, Jafarzadeh-Esfehani Reza, Ghandehari Maryam, Parizadeh Mohammad Reza Seyed , Hassanian Mahdi Seyed , Rezayi Majid , Ghayour-Mobarhan Majid , Ferns A. Gordon and Avan Amir*, Circulating Exosomes as Potential Biomarkers in Cardiovascular Disease, Current Pharmaceutical Design 2018; 24 (37) . https://dx.doi.org/10.2174/1381612825666181219162655