Therapeutic Applications of Liposomal Based Drug Delivery and Drug Targeting for Immune Linked Inflammatory Maladies: A Contemporary View Point

Title:Therapeutic Applications of Liposomal Based Drug Delivery and Drug Targeting for Immune Linked Inflammatory Maladies: A Contemporary View Point

Volume: 18 Issue: 13

Author(s): Mahfoozur Rahman *, Sarwar Beg , Amita Verma, Imran Kazmi, Dinesh Kumar Patel , Firoz Anwar , Fahad A Al Abbasi and Vikas Kumar *

Affiliation:

• Department of Pharmaceutical Sciences, Faculty of Health Sciences, Shalom Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences (SHUATS), Allahabad,India

• Natural Product Drug Discovery Laboratory, Department of Pharmaceutical Sciences, Faculty of Health Sciences, Shalom Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences (SHUATS), Allahabad,India

Keywords: Immune mediated inflammatory disorders, liposomes, cationic liposomes, immuno-liposomes, atherosclerosis, multiple sclerosis.

Abstract: Immune-based inflammatory diseases involve immune related dysregulation in different sites of body, which includes rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, atherosclerosis, etc. Advancements in molecular research have facilitated investigation of their pathogenesis that is involved in inflammatory cytokines cells and several genes. The available drug therapy provides suboptimal therapeutic effects and higher adverse effects. Emergence of liposomal systems of the drugs meant for the above mentioned disease has gained broader importance due to their high treatment efficacy by means of optimal therapeutic drug delivery. Beyond the conventional liposomal formulations, evolution of second generation liposomes including stealth liposomes, cationic liposomes, immuno-liposomes, etc. has gained tremendous attention owing to their drug target potential, diagnostic importance and imaging in treatment of above mentioned immune mediated inflammatory disorders.

Cite this article as:

Rahman Mahfoozur *, Beg Sarwar, Verma Amita, Kazmi Imran , Patel Kumar Dinesh, Anwar Firoz , Al Abbasi A Fahad and Kumar Vikas*, Therapeutic Applications of Liposomal Based Drug Delivery and Drug Targeting for Immune Linked Inflammatory Maladies: A Contemporary View Point, Current Drug Targets 2017; 18 (13) . https://dx.doi.org/10.2174/1389450118666170414113926