Emerging β-Amyloid Therapies for the Treatment of Alzheimers Disease

Title: Emerging β-Amyloid Therapies for the Treatment of Alzheimers Disease

Volume: 9 Issue: 6

Author(s): Kelly A. Conway, Ellen W. Baxter, Kevin M. Felsenstein and Allen B. Reitz

Affiliation:

Keywords: alzheimer disease, amyloid precursor protein, beta-amyloid, beta-secretase, gamma-secretase, aggregation, cholesterol, vaccine

Abstract: Alzheimers Disease (AD) is a progressive neurodegenerative disorder marked by loss of memory, cognition, and behavioral stability. AD is defined pathologically by extracellular neuritic plaques comprised of fibrillar deposits of β-amyloid peptide (Aβ) and neurofibrillary tangles comprised of paired helical filaments of hyperphosphorylated tau. Current therapies for AD, such as cholinesterase inhibitors, treat the symptoms but do not modify the progression of the disease. The etiology of AD is unclear. However, data from familial AD mutations (FAD) strongly support the “amyloid cascade hypothesis” of AD, i.e. that neurodegeneration in AD is initiated by the formation of neurotoxic β-amyloid (Aβ) aggregates, all FAD mutations increase levels of Aβ peptide or density of Aβ deposits. The likely link between Aβ aggregation and AD pathology emphasizes the need for a better understanding of the mechanisms of Aβ production. This review summarizes current therapeutic strategies directed at lowering Aβ levels and decreasing levels of toxic Aβ aggregates through (1) inhibition of the processing of amyloid precursor protein (APP) to Aβ peptide, (2) inhibition, reversal or clearance of Aβ aggregation, (3) cholesterol reduction and (4) Aβ immunization.

Cite this article as:

Conway A. Kelly, Baxter W. Ellen, Felsenstein M. Kevin and Reitz B. Allen, Emerging β-Amyloid Therapies for the Treatment of Alzheimers Disease, Current Pharmaceutical Design 2003; 9 (6) . https://dx.doi.org/10.2174/1381612033391649