Pernicious Anemia: Fundamental and Practical Aspects in Diagnosis

Title:Pernicious Anemia: Fundamental and Practical Aspects in Diagnosis

Volume: 15 Issue: 1

Author(s): Aung Myint Tun, Kyaw Zin Thein, Zin War Myint and Thein Hlaing Oo*

Affiliation:

• The University of Texas M.D. Anderson Cancer Center, Section of Thrombosis & Benign Hematology (Unit 1464), 1515 Holcombe Blvd., Houston, TX 77030,United States

Keywords: Pernicious anemia, pathophysiology, diagnostic challenges, fundamental aspects, practical approach, cobalamia deficiency.

Abstract: Background: Pernicious Anemia (PA), the most common cause of cobalamin deficiency anemia worldwide, is an autoimmune disease of multifactorial etiologies involving complex environmental and immunological factors. Although it was first reported by Addison in 1849 with subsequent advances in understanding of pathogenesis and molecular biology, diagnosis of PA is still challenging for clinicians because of its complexity and diverse clinical presentations.

Conclusion: Herein, we provide an overview of PA, mainly focusing on its scientific and practical aspects in diagnosis. We also discuss the limitations of currently available diagnostic tools for the evaluation of cobalamin deficiency and PA.

Cite this article as:

Tun Myint Aung, Thein Zin Kyaw, Myint War Zin and Oo Hlaing Thein*, Pernicious Anemia: Fundamental and Practical Aspects in Diagnosis, Cardiovascular & Hematological Agents in Medicinal Chemistry 2017; 15 (1) . https://dx.doi.org/10.2174/1871525715666170203114632